Ruxolitinib withdrawal complicating emergency aortic root replacement

Interact Cardiovasc Thorac Surg. 2022 Jun 15;35(1):ivac143. doi: 10.1093/icvts/ivac143.

Abstract

Ruxolitinib, a Janus kinase inhibitor, is associated with severe withdrawal phenomena. Adequate tapering is often underemphasized in surgical emergencies and can complicate the postoperative course. We present a case of acute ruxolitinib withdrawal in a gentleman undergoing emergency cardiac surgery.

Keywords: Aortic syndrome; Cardiac surgery; Ruxolitinib.

Publication types

  • Case Reports

MeSH terms

  • Aortic Valve
  • Humans
  • Nitriles
  • Primary Myelofibrosis* / complications
  • Pyrazoles / adverse effects
  • Pyrimidines

Substances

  • Nitriles
  • Pyrazoles
  • Pyrimidines
  • ruxolitinib