We report enterovirus D68 circulation in Maryland, USA, during September-October 2021, which was associated with a spike in influenza-like illness. The characterized enterovirus D68 genomes clustered within the B3 subclade that circulated in 2018 in Europe and the United States.
Keywords: EV-D68; Maryland; United States; enterovirus; enterovirus D68; influenza-like illness; respiratory infections; viruses.