Something's gotta give at the centromeric chromatin foundation of the kinetochore

Mol Cell. 2022 Jun 2;82(11):1976-1978. doi: 10.1016/j.molcel.2022.05.011.

Abstract

Structures of the reconstituted human inner kinetochore complex by Pesenti et al. (2022) and Yatskevich et al. (2022) raise the question of whether it is the CENP-A nucleosome or the CCAN complex itself that provides the foundation for kinetochore assembly.

Publication types

  • Research Support, N.I.H., Extramural
  • Comment

MeSH terms

  • Centromere / genetics
  • Centromere Protein A / genetics
  • Chromatin* / genetics
  • Humans
  • Kinetochores*
  • Nucleosomes / genetics

Substances

  • Centromere Protein A
  • Chromatin
  • Nucleosomes