A novelly designed protein antagonist confers potent neutralization against SARS-CoV-2 variants of concern

Affiliations

• ¹ Department of Pathogen Biology, School of Basic Medicine, Tongji Medical College, Huazhong University of Science and Technology, 13 Hangkong Road, Wuhan, Hubei, 430030, China.
• ² Institute of Health Inspection and Testing, Hubei Provincial Center for Disease Control and Prevention (Hubei CDC), Wuhan, Hubei, 430079, China.
• ³ State Key Laboratory of Virology and Hubei Province Key Laboratory of Allergy and Immunology, Institute of Medical Virology, TaiKang Medical School, Wuhan University, Wuhan, 430071, China.
• ⁴ Kangma Healthcode (Shanghai) Biotech, Co., Ltd., 118 Furonghua Road, Building No.15, Shanghai, 201203, China.
• ⁵ State Key Laboratory of Virology, Modern Virology Research Center, RNA Institute, College of Life Sciences, Wuhan University, Wuhan, 430072, China; Institute for Vaccine Research, Animal Bio-Safety Level III Laboratory at Center for Animal Experiments, Wuhan University School of Medicine, Wuhan, 430071, China.
• ⁶ State Key Laboratory of Virology, Wuhan Institute of Virology, Chinese Academy of Sciences, Wuhan, Hubei, 430071, China; University of Chinese Academy of Sciences, Beijing, 100049, China.
• ⁷ Kangma Healthcode (Shanghai) Biotech, Co., Ltd., 118 Furonghua Road, Building No.15, Shanghai, 201203, China. Electronic address: [email protected].
• ⁸ Institute of Health Inspection and Testing, Hubei Provincial Center for Disease Control and Prevention (Hubei CDC), Wuhan, Hubei, 430079, China. Electronic address: [email protected].
• ⁹ State Key Laboratory of Virology and Hubei Province Key Laboratory of Allergy and Immunology, Institute of Medical Virology, TaiKang Medical School, Wuhan University, Wuhan, 430071, China. Electronic address: [email protected].
• ¹⁰ Department of Pathogen Biology, School of Basic Medicine, Tongji Medical College, Huazhong University of Science and Technology, 13 Hangkong Road, Wuhan, Hubei, 430030, China; Department of Pediatrics, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, 430030, China. Electronic address: [email protected].