Title: Jealous protons sour another happy marriage; the story of how TRPV5 and PI(4,5)P2 split up

Mark K C van Goor; Jenny van der Wijst; Joost G J Hoenderop

doi:10.1016/j.ceca.2022.102609

Title: Jealous protons sour another happy marriage; the story of how TRPV5 and PI(4,5)P₂ split up

Cell Calcium. 2022 Jul:105:102609. doi: 10.1016/j.ceca.2022.102609. Epub 2022 May 31.

Authors

Mark K C van Goor¹, Jenny van der Wijst², Joost G J Hoenderop³

Affiliations

¹ Department of Physiology, Radboud Institute for Molecular Life Sciences, Radboudumc, Geert Grooteplein Zuid 26, 6525 GA, Nijmegen, The Netherlands. Electronic address: [email protected].
² Department of Physiology, Radboud Institute for Molecular Life Sciences, Radboudumc, Geert Grooteplein Zuid 26, 6525 GA, Nijmegen, The Netherlands. Electronic address: [email protected].
³ Department of Physiology, Radboud Institute for Molecular Life Sciences, Radboudumc, Geert Grooteplein Zuid 26, 6525 GA, Nijmegen, The Netherlands. Electronic address: [email protected].

PMID: 35667882
DOI: 10.1016/j.ceca.2022.102609

Abstract

TRPV5 is a highly selective calcium channel that finetunes urinary calcium excretion by reabsorbing calcium from the pro-urine. New structural findings show how PTH and pH control TRPV5 activity by altering the binding of endogenous ligands calmodulin and phosphatidylinositol 4,5-bisphosphate (PI(4,5)P₂).

Keywords: Acidification; Calcium homeostasis; Calcium transport; Cryo-EM; PI(4,5)P2; PIP2; Renal calcium,transport; TRPV5.

MeSH terms

Calcium Channels / metabolism
Calcium* / metabolism
Marriage
Protons*
TRPV Cation Channels / metabolism

Substances

Calcium Channels
Protons
TRPV Cation Channels
Calcium