Emergence of Omicron BA.1 and BA.2 variants and concern over vaccine breakthrough infection

Mahnoor Sukaina; Mohammad Mehedi Hasan; Mohammad Yasir Essar

doi:10.1016/j.amsu.2022.103941

Emergence of Omicron BA.1 and BA.2 variants and concern over vaccine breakthrough infection

Ann Med Surg (Lond). 2022 Jul:79:103941. doi: 10.1016/j.amsu.2022.103941. Epub 2022 Jun 6.

Authors

Mahnoor Sukaina¹, Mohammad Mehedi Hasan², Mohammad Yasir Essar^{3

4}

Affiliations

¹ Karachi Medical and Dental College, Karachi, Pakistan.
² Department of Biochemistry and Molecular Biology, Faculty of Life Science, Mawlana Bhashani Science and Technology University, Tangail, Bangladesh.
³ Afghanistan National Charity Organization for Special Diseases (ANCOSD), Kabul, Afghanistan.
⁴ Kabul University of Medical Sciences, Kabul, Afghanistan.

Abstract

The COVID-19 pandemic since 2020 created havoc across the globe. This led to the establishment of effective vaccines to mitigate the virus. Several vaccines are developed to create immunity amongst the population. However, due to emerging variants of SARS-CoV-2, despite a double dose of vaccines, people have still infected that termed vaccine breakthrough infection. This paper aims to highlight the recent re-surging massive outbreak of COVID-19 in China despite mass vaccination and, discuss the issue of vaccine breakthrough infection, possible causes, and recommendations to enhance immunity and curb the transmission.

Keywords: BA.1 variant; BA.2 variant; COVID-19; Fourth recommended COVID-19 vaccine; Recommendation third booster dose; SARS-CoV-2; Vaccine breakthrough infection.