Abstract
Lyophilized onion extract and ether extracts of onions were separated by chromatographic methods into several subfractions and tested for their effects on asthmatic reactions of guinea pigs to allergen, histamine, acetylcholine and platelet-activating factor (PAF) inhalation as well as on thromboxane biosynthesis of human platelets and lung fibroblasts. Onion oils are counteracting the bronchial obstruction due to PAF inhalation.
MeSH terms
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Allium / analysis*
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Animals
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Asthma / physiopathology
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Asthma / prevention & control*
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Blood Platelets / drug effects
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Blood Platelets / metabolism
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Bronchial Provocation Tests
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Cells, Cultured
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Fibroblasts / drug effects
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Fibroblasts / metabolism
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Guinea Pigs
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Humans
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Plant Oils / pharmacology
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Plant Oils / therapeutic use*
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Platelet Activating Factor / antagonists & inhibitors
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Thromboxane B2 / biosynthesis
Substances
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Plant Oils
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Platelet Activating Factor
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Thromboxane B2