Chondroblastomas characteristically occur in skeletally immature patients, and arise within the medullary canal of the epiphysis. We report a rare case of an intracortical chondroblastoma arising in the diaphysis, and occurring in an adult in his 3rd decade of life. Immunohistochemistry results were critical to confirmation of this rare diagnosis, with immunohistochemistry showing S100, DOG1, and H3K36me3 positivity in the neoplastic cells.
Keywords: Chondroblastoma; Diaphyseal bone neoplasm; H3K36 mutation; Intracortical bone neoplasm.
© 2022. The Author(s), under exclusive licence to International Skeletal Society (ISS).