Distinct characteristics of central serous chorioretinopathy according to gender

Sci Rep. 2022 Jun 22;12(1):10565. doi: 10.1038/s41598-022-14777-8.

Abstract

To investigate the differences in clinical and genetic characteristics between males and females with central serous chorioretinopathy (CSC). Consecutive 302 patients (mean age; 56.3 ± 11.7, male/female: 249/53) with CSC were evaluated on the initial presentation. All CSC patients underwent fluorescein angiography and indocyanine green angiography (FA/ICGA), swept-source or spectral-domain optical coherence tomography (OCT), and fundus autofluorescence (FAF) to confirm a diagnosis. All patients were genotyped for rs800292 and rs1329428 variants of CFH using TaqMan technology. On the initial presentation, female patients were significantly older (p = 2.1 × 10-4, female 61.6 ± 12.4 vs male 55.1 ± 11.3) and had thinner subfoveal choroidal thickness (p = 3.8 × 10-5) and higher central retinal thickness (p = 3.0 × 10-3) compared to males. A descending tract was more frequently seen in males than in females (p = 8.0 × 10-4, 18.1% vs 0%). Other clinical characteristics were comparable between the sexes. The risk allele frequency of both variants including CFH rs800292 and CFH rs1329428 was comparable between males and females (CFH rs800292 A allele male 51.2% vs female 47.2%, CFH rs1329428 T allele male 56.2% vs 52.8%). On the initial presentation, age, subfoveal choroidal thickness and central retinal thickness differ between males and females in eyes with CSC. A descending tract may be a strong male finding in CSC.

MeSH terms

  • Adult
  • Aged
  • Central Serous Chorioretinopathy* / diagnostic imaging
  • Central Serous Chorioretinopathy* / genetics
  • Choroid / diagnostic imaging
  • Coloring Agents
  • Female
  • Fluorescein Angiography / methods
  • Humans
  • Indocyanine Green
  • Male
  • Middle Aged
  • Retrospective Studies
  • Tomography, Optical Coherence / methods

Substances

  • Coloring Agents
  • Indocyanine Green