The proliferative and the antifibrotic side of PAX2 in tubular repair

Kidney Int. 2022 Jul;102(1):12-13. doi: 10.1016/j.kint.2022.04.016.

Abstract

Regenerative repair following injury to proximal tubular epithelial cells (PTECs) is essential to restore the kidney to normal function in acute kidney injury. Failure to accomplish this leads to chronic kidney disease. Expression of the paired-box transcription factor Pax2 in PTECs is required for their regenerative proliferation and repair. However, a loss-of-function study now shows that the absence of Pax2 not only impacts PTEC proliferation but also causes myofibroblast recruitment leading to excessive tubulointerstitial fibrosis.

Publication types

  • Research Support, U.S. Gov't, Non-P.H.S.
  • Research Support, N.I.H., Extramural
  • Comment

MeSH terms

  • Acute Kidney Injury* / pathology
  • Animals
  • Epithelial Cells / metabolism
  • Fibrosis
  • Kidney / metabolism
  • Kidney Tubules, Proximal / pathology
  • PAX2 Transcription Factor* / genetics
  • PAX2 Transcription Factor* / metabolism

Substances

  • PAX2 Transcription Factor