Reseach progress in neuroinflammation mechanism in depression
Zhong Nan Da Xue Xue Bao Yi Xue Ban. 2020 Nov 28;45(11):1372-1377.
doi: 10.11817/j.issn.1672-7347.2020.190646.
[Article in
English,
Chinese]
Affiliations
- 1 Institute of Mental Health, Central South University; National Clinical Research Center for Mental Disorders; National Technology Institute on Mental Disorders; Hunan Key Laboratory of Psychiatry and Mental Health, Changsha 410011. [email protected].
- 2 Institute of Mental Health, Central South University; National Clinical Research Center for Mental Disorders; National Technology Institute on Mental Disorders; Hunan Key Laboratory of Psychiatry and Mental Health, Changsha 410011.
- 3 Xiamen Xianyue Hospital, Xiamen Mental Health Center, Xiamen Fujian 361012, China.
- 4 Institute of Mental Health, Central South University; National Clinical Research Center for Mental Disorders; National Technology Institute on Mental Disorders; Hunan Key Laboratory of Psychiatry and Mental Health, Changsha 410011. [email protected].
Neuroinflammation is the innate immune response of the central nervous system, characterized by microglia activation, which can be accompanied with activation of astrocytes and increased levels of inflammatory factors and chemokines.Recent studies indicate that depressive patients have characteristic changes in neuroinflammation, mainly characterized by activation of microglia in the relevant brain regions. At present, the clinical results of positron emission tomography have found that the expression of neuroinflammatory imaging markers in the brain of patients with depression is increased.
神经炎症是中枢神经系统的先天免疫反应，以小胶质细胞激活为特征性表现，可伴有星形胶质细胞激活、炎症因子及趋化因子水平增高。研究发现抑郁症患者存在神经炎症的特征性改变，主要表现为相关脑区中小胶质细胞激活。目前临床上利用正电子发射体层摄影技术发现抑郁症患者脑内神经炎症影像学标志物的表达上调。.
Keywords:
depression; microglia; neuroinflammation; translocator protein.