Clinically unquestionable but histologically deceptive melanomas in acral skin grafts: PRAME confirms its role

Giacomo Santandrea; Riccardo Valli; Moira Ragazzi; Fabio Castagnetti; Michela Lai; Caterina Longo; Simonetta Piana

doi:10.1111/bjd.21715

Clinically unquestionable but histologically deceptive melanomas in acral skin grafts: PRAME confirms its role

Br J Dermatol. 2022 Nov;187(5):804-806. doi: 10.1111/bjd.21715. Epub 2022 Jul 17.

Authors

Giacomo Santandrea^{1

2}, Riccardo Valli¹, Moira Ragazzi¹, Fabio Castagnetti³, Michela Lai^{4

5}, Caterina Longo^{4

5}, Simonetta Piana¹

Affiliations

¹ Arcispedale Santa Maria Nuova, Azienda USL-IRCCS Reggio Emilia, Viale Risorgimento 80, Reggio Emilia, 40123, Italy.
² Clinical and Experimental Medicine PhD Program, University of Modena and Reggio Emilia, Modena, 41121, Italy.
³ Surgery Unit, Arcispedale Santa Maria Nuova, Azienda USL-IRCCS Reggio Emilia, Viale Risorgimento 80, 42123, Reggio Emilia, Italy.
⁴ Centro Oncologico ad Alta Tecnologia Diagnostica-Skin Cancer Unit, Arcispedale Santa Maria Nuova, Azienda USL-IRCCS Reggio Emilia, Reggio Emilia, Italy.
⁵ Department of Dermatology, University of Modena and Reggio Emilia, 41121, Modena, Italy.

PMID: 35762291
DOI: 10.1111/bjd.21715

Abstract

The aim of this study was to investigate the role of PRAME in reducing the risk of an underestimation of tumour margins, in a consecutive series of acral melanomas recurring on skin grafts.

Publication types

Letter

MeSH terms

Antigens, Neoplasm
Humans
Melanoma* / pathology
Melanoma* / surgery
Skin Neoplasms* / pathology
Skin Neoplasms* / surgery
Skin Transplantation

Substances

PRAME protein, human
Antigens, Neoplasm