Contrast-induced acute kidney injury in patients submitted to coronary angioplasty: prospective cohort

Rev Esc Enferm USP. 2022 Jul 4;56(spe):e20210435. doi: 10.1590/1980-220X-REEUSP-2021-0435en. eCollection 2022.
[Article in English, Portuguese]

Abstract

Objective: To analyze the incidence, risk factors, and associations of clinical outcomes for contrast-induced acute kidney injury (CI-AKI) in patients with acute coronary syndrome (ACS) after coronary angioplasty.

Method: Prospective cohort of 182 patients followed for three months after undergoing angioplasty, from July 2020 to June 2021. The analyzed variables were sociodemographic, clinical, and those related to the procedure.

Results: The incidence of CI-AKI was 35.7% (n = 65) and was associated with old age, diabetes mellitus, and chronic kidney disease (p = 0.004, p < 0.001, and p = 0.009, respectively). Out of the 17 patients who died within 90 days, 76.5% had CI-AKI (n = 13), the odds ratio between death and CI-AKI was approximately 7.2 times (95% confidence interval (CI), [2.41;26.36]; p = 0.001). The decrease of one unit in the patient's baseline hemoglobin showed a 6.5% increase for CI-AKI (95% CI, [-0.089; -0.040]; p < 0.0001).

Conclusion: CI-AKI is prevalent in patients with ACS after angioplasty and is related to diabetes mellitus and chronic kidney disease, showing high mortality rates.

MeSH terms

  • Acute Coronary Syndrome* / chemically induced
  • Acute Coronary Syndrome* / epidemiology
  • Acute Coronary Syndrome* / surgery
  • Acute Kidney Injury* / chemically induced
  • Acute Kidney Injury* / epidemiology
  • Angioplasty / adverse effects
  • Contrast Media / adverse effects
  • Diabetes Mellitus*
  • Humans
  • Prospective Studies
  • Renal Insufficiency, Chronic* / complications
  • Renal Insufficiency, Chronic* / epidemiology

Substances

  • Contrast Media