Chitosan-modified nanocarriers as carriers for anticancer drug delivery: Promises and hurdles

Fahad Saad Alhodieb; Md Abul Barkat; Harshita Abul Barkat; Hazrina Ab Hadi; Muhammad Idreesh Khan; Fauzia Ashfaq; Mohammad Akhlaquer Rahman; Mohd Zaheen Hassan; Abdulkareem A Alanezi

doi:10.1016/j.ijbiomac.2022.06.201

Chitosan-modified nanocarriers as carriers for anticancer drug delivery: Promises and hurdles

Int J Biol Macromol. 2022 Sep 30:217:457-469. doi: 10.1016/j.ijbiomac.2022.06.201. Epub 2022 Jul 5.

Authors

Fahad Saad Alhodieb¹, Md Abul Barkat², Harshita Abul Barkat³, Hazrina Ab Hadi⁴, Muhammad Idreesh Khan⁵, Fauzia Ashfaq⁶, Mohammad Akhlaquer Rahman⁷, Mohd Zaheen Hassan⁸, Abdulkareem A Alanezi⁹

Affiliations

¹ Department of Clinical Nutrition, College of Applied Health Sciences in Arrass, Qassim University, P.O. BOX:6666, Buraidah, 51452, Saudi Arabia. Electronic address: [email protected].
² Department of Pharmaceutics, College of Pharmacy, University of Hafr Al-Batin, Al Jamiah, Hafr Al Batin 39524, Saudi Arabia. Electronic address: [email protected].
³ Department of Pharmaceutics, College of Pharmacy, University of Hafr Al-Batin, Al Jamiah, Hafr Al Batin 39524, Saudi Arabia; Dermatopharmaceutics Research Group, Department of Pharmaceutical Technology, Faculty of Pharmacy, International Islamic University Malaysia, Kuantan, Pahang 25200, Malaysia. Electronic address: [email protected].
⁴ Dermatopharmaceutics Research Group, Department of Pharmaceutical Technology, Faculty of Pharmacy, International Islamic University Malaysia, Kuantan, Pahang 25200, Malaysia. Electronic address: [email protected].
⁵ Department of Clinical Nutrition, College of Applied Health Sciences in Arrass, Qassim University, P.O. BOX:6666, Buraidah, 51452, Saudi Arabia. Electronic address: [email protected].
⁶ Department of Clinical Nutrition, College of Applied Medical Sciences, Jazan University, Jazan, Saudi Arabia. Electronic address: [email protected].
⁷ Department of Pharmaceutics, College of Pharmacy, Taif University, Taif 21974, Saudi Arabia. Electronic address: [email protected].
⁸ Department of Pharmaceutical Chemistry, College of Pharmacy, King Khalid University, Abha, Saudi Arabia. Electronic address: [email protected].
⁹ Department of Pharmaceuics, College of pharmacy, University of Hafr Al-Batin, Al Jamiah, Hafr Al-Batin 39524, Saudi Arabia. Electronic address: [email protected].

PMID: 35798082
DOI: 10.1016/j.ijbiomac.2022.06.201

Abstract

With the advent of drug delivery, various polymeric materials are being explored to fabricate numerous nanocarriers. Each polymer is associated with a few characteristics attributes which further facilitate its usage in drug delivery. One such polymer is chitosan (CS), which is extensively employed to deliver a variety of drugs to various targets, especially to cancer cells. The desired properties like biological origin, bio-adhesive, biocompatibility, the scope of chemical modification, biodegradability and controlled drug release make it a highly rough after polymer in pharmaceutical nanotechnology. The present review attempts to compile various chemical modifications on CS and showcase the outcomes of the derived nanocarriers, especially in cancer chemotherapy and drug delivery.

Keywords: Biocompatibility; Biodegradability; Chemotherapy; Chitin; Derivatives; Micelles; Nanoparticles; Nanotechnology.

Publication types

Review

MeSH terms

Antineoplastic Agents* / chemistry
Chitosan* / chemistry
Drug Carriers / chemistry
Drug Delivery Systems
Nanoparticles* / chemistry
Polymers

Substances

Antineoplastic Agents
Drug Carriers
Polymers
Chitosan