Asymmetric Hydrogenation by Relay Catalysis with FLPs and CPAs: Stereodivergent Synthesis of 3-Substituted Flavanones

J Org Chem. 2022 Aug 5;87(15):10544-10549. doi: 10.1021/acs.joc.2c01278. Epub 2022 Jul 7.

Abstract

To access flavanones bearing two contiguous stereogenic centers, a metal-free asymmetric hydrogenation of racemic 3-alkylidene flavanones has been developed by relay catalysis with achiral FLPs and chiral phosphoric acids, which represents a successful detour for the challenging hydrogenation of 3-substituted flavones. A wide range of trans- and cis-flavanones were obtained in high yields and ≤97% ee.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Catalysis
  • Flavanones*
  • Hydrogenation
  • Phosphoric Acids
  • Stereoisomerism

Substances

  • Flavanones
  • Phosphoric Acids