Long-Term Comprehensive Management of Bilateral Limbal Stem Cell Deficiency Secondary to Severe Chemical Burn: 10 Years of Follow-Up

Ocul Immunol Inflamm. 2023 Oct;31(8):1629-1634. doi: 10.1080/09273948.2022.2090965. Epub 2022 Jul 11.

Abstract

Purpose: To describe the long-term management of bilateral limbal stem cell deficiency secondary to a severe chemical burn.

Methods: Descriptive case report.

Importance: This case highlights the importance of early intervention in ocular chemical burns for the preservation of tissue integrity and avoidance of perforation. We also review the use of proper ocular surface reconstructive techniques to restore the function of the limbal area, as well as the immunomodulatory strategies and follow-up needed for these interventions.

Keywords: Keratolimbal allograft (KLAL); limbal stem cell deficiency; ocular burns; ocular surface; simple limbal epithelial transplantation (SLET).

Publication types

  • Case Reports

MeSH terms

  • Burns, Chemical* / complications
  • Burns, Chemical* / diagnosis
  • Burns, Chemical* / surgery
  • Corneal Diseases* / diagnosis
  • Corneal Diseases* / etiology
  • Epithelium, Corneal*
  • Follow-Up Studies
  • Humans
  • Limbal Stem Cells
  • Limbus Corneae*
  • Stem Cell Transplantation / adverse effects
  • Stem Cell Transplantation / methods
  • Visual Acuity