Improvement of chronic GVHD after oral treatment with Clostridium butyricum (Miya BM)

Hiroyasu Kaya; Hirokazu Okumura; Shin Ishizawa

doi:10.1016/j.anaerobe.2022.102612

Improvement of chronic GVHD after oral treatment with Clostridium butyricum (Miya BM)

Anaerobe. 2022 Aug:76:102612. doi: 10.1016/j.anaerobe.2022.102612. Epub 2022 Jul 14.

Authors

Hiroyasu Kaya¹, Hirokazu Okumura², Shin Ishizawa³

Affiliations

¹ Department of Infectious Diseases, Toyama Prefectural Central Hospital, Toyama, Japan. Electronic address: [email protected].
² Department of Hematology, Toyama Prefectural Central Hospital, Toyama, Japan.
³ Department of Pathology, Toyama Prefectural Central Hospital, Toyama, Japan.

PMID: 35840013
DOI: 10.1016/j.anaerobe.2022.102612

Abstract

We report a case with leukoplakia of the tongue as a manifestation of chronic graft versus host disease after allogeneic stem cell transplantation for acute promyelocytic leukemia treated with Clostridium butyricum tablets. His leukoplakia subsequently disappeared and his regulatory T cells increased after three months.

Keywords: Chronic graft-versus-host disease; Clostridium butyricum; Leukoplakia; Regulatory T cell.

Publication types

Case Reports

MeSH terms

Administration, Oral
Clostridium butyricum*
Graft vs Host Disease* / diagnosis
Graft vs Host Disease* / drug therapy
Hematopoietic Stem Cell Transplantation* / adverse effects
Humans
Leukoplakia