Lymphocyte alterations in patients with Common Variable Immunodeficiency (CVID) and autoimmune manifestations

Introduction: Autoimmunity is a common feature in CVID patients. To date the mechanisms leading to the development of such complications are not fully elucidated.

Materials and methods: Data from 122 CVID patients subdivided in three groups based on the absence of autoimmunity (n-AI) or the presence of hematologic autoimmune phenomena (Cy-AI) or non-hematologic autoimmune phenomena (n-Cy-AI) were evaluated.

Results: We identified a total of 128 autoimmune manifestations in 55/122 patients (45.1%). 30/122 (24.6%) patients presented hematologic autoimmune phenomena while 29/122 (23.8%) presented gastrointestinal autoimmune involvement. Immune thrombocytopenia was the most common manifestation (27/122; 22.1%), followed by autoimmune hemolytic anemia (18/122; 14.8%) and autoimmune enteropathy (17/122; 13.9%). Cy-AI patients displayed higher CD4⁺ effector memory and terminally differentiated CD8⁺ cells with lower percentages of naïve and recent thymic emigrants (RTEs) CD4⁺ cells and a significant expansion of the CD19^hiCD21^low population.

Conclusions: CVID patients developing autoimmune cytopenias display characteristic immune phenotypic features.