Breadth and Dynamics of Human Norovirus-Specific Antibodies in the First Year of Life

J Pediatric Infect Dis Soc. 2022 Oct 25;11(10):463-466. doi: 10.1093/jpids/piac067.

Abstract

We measured antibody binding to diverse norovirus virus-like particles over 12 months in 16 children. All had maternal antibodies at 2 months, with estimated lowest levels at 5 months of age. Antibody increases after 3 months suggested natural infections. This information could guide the timing of future norovirus vaccines.

Keywords: acute gastroenteritis; antibodies; immunity; infants; multiplex Luminex assay; norovirus; vaccination.

MeSH terms

  • Antibodies, Viral
  • Caliciviridae Infections*
  • Child
  • Gastroenteritis*
  • Humans
  • Norovirus*

Substances

  • Antibodies, Viral