Metabolic changes associated with two endocrine abnormalities in dogs: elevated fructosamine and low thyroxine

Introduction: Metabolomics studies in canine endocrine abnormalities are sparse and basic information on these abnormalities must be generated.

Objectives: To characterize the metabolic changes associated with elevated fructosamine, reflecting poor glycemic control, and low thyroxine, a thyroid hormone controlling metabolism.

Methods: Leftovers of clinical serum samples; 25 controls, 79 high fructosamine, and 47 low thyroxine, were analyzed using ¹H NMR and differences were evaluated using Firth logistic regression.

Results: Both high fructosamine and low thyroxine were associated with changes in concentrations of multiple metabolites, including glycoprotein acetyls and lipids.

Conclusion: These findings suggest promising makers for further research and clinical validation.