Point of care creatinine derived eGFR measurement in capillary blood for identifying patients at risk

Sandrine Lemoine; Anne-Cécile Rouveure; Laurence Dubourg; Solenne Pelletier; Christelle Marolho; Evelyne Decullier; Maurice Laville

doi:10.1016/j.plabm.2022.e00296

Point of care creatinine derived eGFR measurement in capillary blood for identifying patients at risk

Pract Lab Med. 2022 Jul 14:31:e00296. doi: 10.1016/j.plabm.2022.e00296. eCollection 2022 Aug.

Authors

Sandrine Lemoine^{1

2}, Anne-Cécile Rouveure³, Laurence Dubourg¹, Solenne Pelletier³, Christelle Marolho⁴, Evelyne Decullier⁴, Maurice Laville^{3

2}

Affiliations

¹ Department of Nephrology and Renal Function, Edouard Herriot Hospital, Hospices Civils de Lyon, France.
² INSERM U1060 CarMeN, Lyon, France.
³ Department of Nephrology, Lyon Sud University Hospital, France.
⁴ Hospices Civils de Lyon, Pôle Santé Publique, Service Recherche et Epidémiologie Cliniques, Lyon, France.

Abstract

Introduction: The aim of the study was to assess the clinical reliability of eGFR values estimated with a creatinine measurement from a point of care (StatSensor®) compared with measured GFR (mGFR) by a gold standard method.

Methods: We prospectively included 113 patients undergoing renal function assessment. We compared eGFR using creatinine from capillary blood or venous blood measured by StatSensor® and measured GFR (mGFR) by Passing Bablok regression. Performance of eGFR was estimated by biais, precision and accuracy.

Results: A total of 113 subjects were included. Median eGFR values were 59 (10-132), 52 (10-123) and 51 (10-131) ml/min/1.73 m² for enzymatic, capillary and venous measurements, respectively. There was no difference between P30 and P10 for the three eGFR values (p = 0.11 and p = 0.1 respectively). StatSensor® eGFR tended to be underestimated compared to mGFR. For CKD stage 4/5 patients, concordance was 79 and 84% for eGFR with capillary creatinine and venous creatinine respectively. For mGFR< 60 ml/min/1.73 m², concordance was 84 and 88% with capillary creatinine and venous creatinine respectively.

Conclusion: The use of a handheld blood creatinine monitoring system with eGFR calculation provides a good estimation of GFR and allow to identify patients at high risk of acute kidney injury.