Case Report: Reversible Hyperglycemia Following Rapamycin Treatment for Atypical Choroid Plexus Papilloma in an Infant

Jiale Liu; Minjie Luo; Siyuan Lv; Shaohua Tao; Zhu Wu; Lihua Yu; Danna Lin; Lulu Huang; Li Wu; Xu Liao; Juan Zi; Xiaorong Lai; Yuting Yuan; Wangming Zhang; Lihua Yang

doi:10.3389/fendo.2022.865913

Case Report: Reversible Hyperglycemia Following Rapamycin Treatment for Atypical Choroid Plexus Papilloma in an Infant

Front Endocrinol (Lausanne). 2022 Jul 5:13:865913. doi: 10.3389/fendo.2022.865913. eCollection 2022.

Authors

Jiale Liu¹, Minjie Luo², Siyuan Lv², Shaohua Tao³, Zhu Wu³, Lihua Yu¹, Danna Lin¹, Lulu Huang¹, Li Wu¹, Xu Liao¹, Juan Zi¹, Xiaorong Lai¹, Yuting Yuan¹, Wangming Zhang², Lihua Yang¹

Affiliations

¹ Department of Pediatric Hematology, Zhujiang Hospital, Southern Medical University, Guangzhou, China.
² Department of Pediatric Neurosurgery, Zhujiang Hospital, Southern Medical University, Guangzhou, China.
³ Department of Pediatric Intensive Care Unit, Zhujiang Hospital, Southern Medical University, Guangzhou, China.

Abstract

In this study, atypical choroid plexus papilloma was treated with high-dose rapamycin for 17 days preoperatively in an infant. Rapamycin significantly reduced the blood supply to the tumor while reducing the tumor volume, and most of the tumor was resected successfully. However, the infant developed hyperglycemia related to the rapamycin dose, which was effectively controlled by adjusting the dose and applying insulin.

Keywords: atypical choroid plexus papilloma; case report; infant; insulin; rapamycin; reversible hyperglycemia.

Publication types

Case Reports

MeSH terms

Choroid Plexus Neoplasms* / pathology
Choroid Plexus Neoplasms* / therapy
Glioma*
Humans
Hyperglycemia* / chemically induced
Hyperglycemia* / drug therapy
Infant
Papilloma, Choroid Plexus* / pathology
Papilloma, Choroid Plexus* / surgery
Sirolimus / adverse effects

Substances

Sirolimus