Epidemiology of Complicated Urinary Tract Infections due to Enterobacterales Among Adult Patients Presenting in Emergency Departments Across the United States

Thomas P Lodise; Teena Chopra; Brian H Nathanson; Katherine Sulham; Mauricio Rodriguez

doi:10.1093/ofid/ofac315

Epidemiology of Complicated Urinary Tract Infections due to Enterobacterales Among Adult Patients Presenting in Emergency Departments Across the United States

Open Forum Infect Dis. 2022 Jun 24;9(7):ofac315. doi: 10.1093/ofid/ofac315. eCollection 2022 Jul.

Authors

Thomas P Lodise¹, Teena Chopra², Brian H Nathanson³, Katherine Sulham⁴, Mauricio Rodriguez⁴

Affiliations

¹ Department of Pharmacy Practice, Albany College of Pharmacy and Health Sciences, Albany, New York, USA.
² School of Medicine and Division of Infectious Diseases, Wayne State University, Detroit, Michigan, USA.
³ OptiStatim LLC, Longmeadow, Massachusetts, USA.
⁴ Spero Therapeutics, Cambridge, Massachusetts, USA.

Abstract

In this multicenter study of adult patients who presented to the emergency department with an Enterobacterales complicated urinary tract infection (cUTI), high rates of resistance and co-resistance to commonly used oral antibiotics (fluoroquinolones, trimethoprim-sulfamethoxazole, nitrofurantoin, and third-generation cephalosporins) were observed.

Keywords: cUTI; epidemiology; resistance; urinary tract infection.