Temporal control of protein labeling by a photo-caged benzaldehyde motif and discovery of host cell factors of avian influenza virus infection

Nicholas Asiimwe; Jung Hoon Lee; Kyung Tae Hong; Dhiraj P Murale; Md Mamunul Haque; Dong-Hoon Kim; Jun-Seok Lee

doi:10.1039/d2cc04091c

Temporal control of protein labeling by a photo-caged benzaldehyde motif and discovery of host cell factors of avian influenza virus infection

Chem Commun (Camb). 2022 Aug 18;58(67):9345-9348. doi: 10.1039/d2cc04091c.

Authors

Nicholas Asiimwe¹, Jung Hoon Lee², Kyung Tae Hong¹, Dhiraj P Murale³, Md Mamunul Haque², Dong-Hoon Kim², Jun-Seok Lee²

Affiliations

¹ Bio-Med Program KIST-School UST, Korea University College of Medicine, Seoul, Republic of Korea.
² Department of Pharmacology, Korea University College of Medicine, Seoul 02792, Republic of Korea. [email protected].
³ Center for Advanced Biomolecular Recognition, Korea Institute of Science and Technology, Seoul 02792, Republic of Korea.

PMID: 35924753
DOI: 10.1039/d2cc04091c

Abstract

Photo-caged benzaldehyde probes using o-nitrophenylethylene glycol were designed for photo-activated electrophile generation. Using photo-activated electrophile generating probes, we successfully revealed under-represented host cell response factors using an avian influenza virus infection model.

MeSH terms

Animals
Benzaldehydes / pharmacology
Influenza A virus*
Influenza in Birds*

Substances

Benzaldehydes