[Kaposi sarcoma-a complication of treatment refractory ulcerative colitis]

Pathologie (Heidelb). 2022 Sep;43(5):372-376. doi: 10.1007/s00292-022-01090-4. Epub 2022 Jun 24.
[Article in German]

Abstract

We report on the incidental finding of Kaposi sarcoma of the colon in the setting of refractory ulcerative colitis treatment. The patient was under long-term immunosuppression with infliximab, vedolizumab, and prednisolone. Serologic analysis excluded human immunodeficiency virus (HIV) infection.

Wir berichten über den Zufallsbefund eines Kaposi-Sarkoms des Kolons bei schwerer therapierefraktärer Colitis ulcerosa. Die Patientin war zuvor lange immunsuppressiv mit Infliximab, Vedolizumab und Prednisolon behandelt worden. Serologische Untersuchungen schlossen eine HIV(„human immunodeficiency virus“)-Infektion aus.

Keywords: Chronic inflammatory bowel disease; HIV-independent Kapos sarcoma; Immunomodulation; T cell suppression; α4β7-Integrin inhibitor.

MeSH terms

  • Colitis, Ulcerative* / complications
  • Humans
  • Immunosuppression Therapy
  • Infliximab / adverse effects
  • Sarcoma, Kaposi* / drug therapy

Substances

  • Infliximab