Untangling the tumorigenic role of homotrimeric collagen I

Cancer Cell. 2022 Aug 8;40(8):802-804. doi: 10.1016/j.ccell.2022.07.007.

Abstract

Pancreatic ductal adenocarcinoma is characterized by a complex microenvironment. In this issue of Cancer Cell, Chen and colleagues define an oncogenic role of tumor-cell-produced collagen I homotrimers, wherein tumor development is promoted by integrin α3/β1-dependent activation of tumor cell signaling and modulation of tumor microbiome and immunity.

Publication types

  • Research Support, Non-U.S. Gov't
  • Comment

MeSH terms

  • Carcinoma, Pancreatic Ductal* / drug therapy
  • Carcinoma, Pancreatic Ductal* / pathology
  • Collagen Type I
  • Humans
  • Integrin beta1
  • Pancreatic Neoplasms* / pathology
  • Signal Transduction
  • Tumor Microenvironment

Substances

  • Collagen Type I
  • Integrin beta1