Cofactors: a new layer of specificity to enhancer regulation

Elisa Kreibich; Arnaud R Krebs

doi:10.1016/j.tibs.2022.07.008

Cofactors: a new layer of specificity to enhancer regulation

Trends Biochem Sci. 2022 Dec;47(12):993-995. doi: 10.1016/j.tibs.2022.07.008. Epub 2022 Aug 13.

Authors

Elisa Kreibich¹, Arnaud R Krebs²

Affiliations

¹ EMBL Heidelberg, Meyerhofstraße 1, 69117 Heidelberg, Germany; Faculty of Biosciences, Collaboration for Joint PhD Degree between EMBL and Heidelberg University, Heidelberg, Germany.
² EMBL Heidelberg, Meyerhofstraße 1, 69117 Heidelberg, Germany. Electronic address: [email protected].

PMID: 35970663
DOI: 10.1016/j.tibs.2022.07.008

Abstract

Cofactors are essential effectors of the transcription control machinery. How this functionally diverse group of factors is used in the genome remains elusive. A recent study by Neumayr, Haberle et al. sheds light on this question, showing that enhancers depend on defined combinations of cofactors for their activation.

Keywords: cofactors; enhancer; gene regulation; transcription factors.

Publication types

Comment

MeSH terms

Enhancer Elements, Genetic*
Gene Expression Regulation
Promoter Regions, Genetic
Transcription Factors* / genetics
Transcription Factors* / metabolism

Substances

Transcription Factors