Objective: To analyze the related factors of worsening renal function (WRF) in patients with acute right ventricular myocardial infarction (RVMI) during hospitalization. Methods: A total of 98 patients with acute RVMI admitted to the emergency comprehensive ward of Beijing Anzhen Hospital from August 2011 to January 2020 were enrolled in this cross-sectional study. According to the situation of WRF, the patients were divided into non-WRF group (76 cases) and WRF group (22 cases). WRF was defined as ≥0.3 mg/dL increase in serum creatinine level from baseline on day 6 of hospitalization (if hospital stay<6 days, it was at discharge). Baseline data, intravenous fluid infusion, diuretic and significant positive balance of patients' intake and output volume [any 24 h intakes and outputs ≥1 000 ml or any consecutive 72 h intakes and outputs ≥2 000 ml within 6 d of hospitalization (if hospitalization<6 d, it was from admission to discharge)] were obtained, and the differences of above indicators between the two groups were analyzed. Multiple logistic regression model was used to analyze the related factors of WRF. Results: The ages of patients in WRF group and non-WRF group were 60 (50, 68) and 63 (52, 72) years, and the male proportions were 63.6% (14 cases) and 76.3% (58 cases), respectively, and there was no significant difference (all P>0.05). The proportion of positive balance was 31.8% (7 cases) in WRF group, which was higher than 14.5% (11 cases) in non-WRF group (P=0.034). The rate of loop diuretic use in WRF group was 4.5% (1 case), lower than that in non-WRF group 10.5% (8 cases) (P=0.027). After adjusting for age, sex, baseline estimated glomerular filtration rate (eGFR), preoperative isoproterenol/temporary pacemaker/atropine use, significant positive balance of intake and output volume, and loop diuretic use, it was found that eGFR≥60 ml·min-1·1.73 m-2 and significant positive balance were associated with WRF, the OR (95%CI) were 0.71 (0.62-0.86) and 1.21 (1.02-1.43) (both P<0.05); After eliminating the variable of significant positive balance in the above model, loop diuretic use was found to be a correlation factor for WRF, with an OR (95%CI) of 0.89 (0.72-0.97) (P<0.05). Conclusions: Significant positive balance of intake and output volume during hospitalization in patients with acute RVMI is a risk factor for WRF on day 6 or at discharge. In the presence of a significant positive balance, loop diuretic use is a protective factor for WRF.
目的： 分析急性右心室心肌梗死（RVMI）患者住院期间发生肾功能恶化（WRF）的相关因素。 方法： 本研究为横断面研究，选取2011年8月至2020年1月就诊于北京安贞医院急诊综合病房的急性RVMI患者共98例。根据WRF情况分为无WRF组（76例）和WRF组（22例），WRF定义为住院第6天（住院<6 d则为出院时）血肌酐水平较基线升高≥0.3 mg/dl。获取患者基线资料、静脉补液、利尿和出入量明显正平衡［住院6 d内（住院<6 d则为入院至出院前）任意1个24 h入量较出量≥1 000 ml或任意1个连续72 h入量较出量≥2 000 ml］的情况，分析两组间上述指标的差异，同时采用多因素logistic回归模型分析RVMI患者住院期间发生WRF的相关因素。 结果： WRF组和无WRF组患者年龄分别为60（50，68）、63（52，72）岁，男性比例分别为63.6%（14例）、76.3%（58例），差异均无统计学意义（均P>0.05）。WRF组出入量明显正平衡的比例为31.8%（7例），高于无WRF组的14.5%（11例）（P=0.034）；WRF组袢利尿剂使用比例为4.5%（1例），低于无WRF组10.5%（8例）（P=0.027）。调整了年龄、性别、基线估算的肾小球滤过率（eGFR）、术前异丙肾上腺素/临时起搏器/阿托品使用、出入量明显正平衡和袢利尿剂使用后发现，eGFR≥60 ml·min-1·1.73 m-2、出入量明显正平衡是发生WRF的相关因素，OR值（95%CI）分别为0.71（0.62~0.86）、1.21（1.02~1.43）（均P<0.05）；剔除上述模型中的出入量明显正平衡变量后发现，袢利尿剂使用是发生WRF的相关因素，OR值（95%CI）为0.89（0.72~0.97）（P<0.05）。 结论： 急性RVMI患者住院期间出入量明显正平衡是第6天或出院时发生WRF的危险因素；在出入量明显正平衡的情况下，袢利尿剂使用是发生WRF的保护因素。.