Chemoselective tandem SN2'/SN2''/inter- or intramolecular Diels-Alder reaction of γ-vinyl MBH carbonates with phenols and o-hydroxychalcones

Chem Commun (Camb). 2022 Aug 30;58(70):9794-9797. doi: 10.1039/d2cc03771h.

Abstract

An unprecedented consecutive SN2'/SN2'' addition of phenol to γ-vinyl MBH carbonate forms a reactive diene intermediate, followed by a dimerization/elimination process to give functionalized exocyclohexenes with excellent chemoselectivity. When using o-hydroxychalcones as pronucleophiles, an SN2'/SN2''/intramolecular Diels-Alder reaction sequence occurs, selectively producing a series of pharmaceutically intriguing tricyclic chromane derivatives with good diastereoselectivity. The good nucleophilicity and fair nucleofugicity exhibited by phenoxy anion play a pivotal role in the SN2'' addition step.

MeSH terms

  • Anions
  • Carbonates*
  • Cycloaddition Reaction
  • Phenols*

Substances

  • Anions
  • Carbonates
  • Phenols