Single-cell DNA sequencing reveals order of mutational acquisition in TRAF7/AKT1 and TRAF7/KLF4 mutant meningiomas

Helin Dogan; Christina Blume; Areeba Patel; Gerhard Jungwirth; Lisa Sogerer; Miriam Ratliff; Ralf Ketter; Christel Herold-Mende; David T W Jones; Wolfgang Wick; Philipp Vollmuth; Klaus Zweckberger; David Reuss; Andreas von Deimling; Felix Sahm

doi:10.1007/s00401-022-02485-6

Single-cell DNA sequencing reveals order of mutational acquisition in TRAF7/AKT1 and TRAF7/KLF4 mutant meningiomas

Acta Neuropathol. 2022 Oct;144(4):799-802. doi: 10.1007/s00401-022-02485-6. Epub 2022 Aug 19.

Authors

Helin Dogan^{1

2

3}, Christina Blume^{1

2

4}, Areeba Patel^{1

2

4}, Gerhard Jungwirth⁵, Lisa Sogerer⁶, Miriam Ratliff⁷, Ralf Ketter⁸, Christel Herold-Mende⁵, David T W Jones^{9

10}, Wolfgang Wick^{11

12}, Philipp Vollmuth¹³, Klaus Zweckberger⁵, David Reuss^{1

2}, Andreas von Deimling^{1

2}, Felix Sahm^{14

15}

Affiliations

¹ Department of Neuropathology, University Hospital Heidelberg, Heidelberg, Germany.
² Clinical Cooperation Unit Neuropathology (B300), German Cancer Consortium (DKTK), German Cancer Research Center (DKFZ), Im Neuenheimer Feld 224, 69120, Heidelberg, Germany.
³ Faculty of Medicine, Heidelberg University, Heidelberg, Germany.
⁴ Faculty of Biosciences, Heidelberg University, Heidelberg, Germany.
⁵ Department of Neurosurgery, University Hospital Heidelberg, Heidelberg, Germany.
⁶ Faculty of Medicine, Technical University of Munich, Munich, Germany.
⁷ Department of Neurosurgery, University Hospital Mannheim, Mannheim, Germany.
⁸ Department of Neurosurgery, University Hospital Saarland, Homburg, Saar, Germany.
⁹ Hopp Children's Cancer Center (KiTZ), Heidelberg, Germany.
¹⁰ Division of Pediatric Glioma Research, German Cancer Research Center (DKFZ), Heidelberg, Germany.
¹¹ Clinical Cooperation Unit Neurooncology, German Consortium for Translational Cancer Research (DKTK), German Cancer Research Center (DKFZ), Heidelberg, Germany.
¹² Department of Neurology and Neurooncology Program, National Center for Tumor Diseases, Heidelberg University Hospital, Heidelberg, Germany.
¹³ Department of Neuroradiology, Heidelberg University Hospital, Heidelberg, Germany.
¹⁴ Department of Neuropathology, University Hospital Heidelberg, Heidelberg, Germany. [email protected].
¹⁵ Clinical Cooperation Unit Neuropathology (B300), German Cancer Consortium (DKTK), German Cancer Research Center (DKFZ), Im Neuenheimer Feld 224, 69120, Heidelberg, Germany. [email protected].

No abstract available

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Humans
Meningeal Neoplasms* / genetics
Meningioma* / genetics
Mutation / genetics
Proto-Oncogene Proteins c-akt / genetics
Proto-Oncogene Proteins c-akt / metabolism
Sequence Analysis, DNA
Tumor Necrosis Factor Receptor-Associated Peptides and Proteins / genetics

Substances

TRAF7 protein, human
Tumor Necrosis Factor Receptor-Associated Peptides and Proteins
AKT1 protein, human
Proto-Oncogene Proteins c-akt