Erdheim-Chester disease long-bone osteosclerosis can be reproduced with a xenografted mouse model and its pathogenesis may involve dysregulation of bone metabolism key cytokines

Affiliations

• ¹ Sorbonne Université, Assistance Publique-Hôpitaux de Paris, Service de Médecine Interne 2, Institut E3M, Centre National de Référence des Histiocytoses, Hôpital Pitié-Salpêtrière, Paris, France.
• ² Laboratory of Molecular Mechanisms of Hematologic Disorders and Therapeutic Implications, INSERM UMR1163, Université de Paris, Imagine Institute, Paris, France.
• ³ EA4340-BECCOH, Versailles University and Département de Pathologie, Hôpital Ambroise Paré, AP-HP, Boulogne, France.
• ⁴ AP-HP, Department of Adult Hematology, Hôpital Necker, University of Paris, Paris, France.