Resveratrol from Dietary Supplement to a Drug Candidate: An Assessment of Potential

Pharmaceuticals (Basel). 2022 Aug 1;15(8):957. doi: 10.3390/ph15080957.

Abstract

Resveratrol (RVT) is a well known phyto-chemical and is widely used in dietary supplements and botanical products. It shows a wide range of pharmacological/beneficial effects. Therefore, it can be a potential candidate to be developed as phyto-pharmaceutical. Multiple diseases are reported to be treated by the therapeutic effect of RVT since it has antioxidant, anti-cancer activity and anti-inflammatory activities. It also has a major role in diabetes, arthritis, cardiac disorder and platelet aggregation etc. The major requirements are establishments regarding safety, efficacy profile and physicochemical characterization. As it is already being consumed in variable maximum daily dose, there should not be a major safety concern but the dose needs to be established for different indications. Clinical trials are also being reported in different parts of the world. Physicochemical properties of the moiety are also well reported. Moreover, due to its beneficial effect on health it leads to the development of some intellectual property in the form of patents.

Keywords: anti-thrombogenic; antioxidants; carcinogenic and anti-aging; cardioprotective; neuroprotective.

Publication types

  • Review

Grants and funding

The authors extend their appreciation to the Deanship of Scientific Research at King Khalid Uni-versity, Saudi Arabia for funding this work through the Research Group Program under Grant No: RGP 2/218/43.