Factor structure and item response of psychosis symptoms among Kenyan adults

Florence Jaguga; Amantia Ametaj; Hannah H Kim; Rocky E Stroud; Charles R Newton; Symon M Kariuki; Edith Kamaru Kwobah; Lukoye Atwoli; Bizu Gelaye; Kristina J Korte

doi:10.1016/j.jad.2022.08.038

Factor structure and item response of psychosis symptoms among Kenyan adults

J Affect Disord. 2022 Nov 15:317:136-141. doi: 10.1016/j.jad.2022.08.038. Epub 2022 Aug 24.

Authors

Affiliations

¹ Department of Mental Health, Moi Teaching and Referral Hospital, Eldoret, Kenya. Electronic address: [email protected].
² Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA, USA.
³ Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA, USA; Stanley Center for Psychiatric Research at Broad Institute of MIT and Harvard, Cambridge, MA, USA.
⁴ Neuroscience Department, Kenya Medical Research Institute - Wellcome Trust Research Program, Kilifi, Kenya; Department of Psychiatry, University of Oxford, Oxford, United Kingdom.
⁵ Neuroscience Department, Kenya Medical Research Institute - Wellcome Trust Research Program, Kilifi, Kenya; Department of Psychiatry, University of Oxford, Oxford, United Kingdom; Department of Public Health, Pwani University, Kilifi, Kenya.
⁶ Department of Mental Health, Moi Teaching and Referral Hospital, Eldoret, Kenya.
⁷ Department of Internal Medicine, Medical College East Africa, Aga Khan University, Nairobi, Kenya.
⁸ Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA, USA; Stanley Center for Psychiatric Research at Broad Institute of MIT and Harvard, Cambridge, MA, USA; Department of Psychiatry, Massachusetts General Hospital, Boston, MA, USA; Department of Psychiatry, Harvard Medical School, Boston, MA, USA.
⁹ Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA, USA; Department of Psychiatry, Massachusetts General Hospital, Boston, MA, USA; Department of Psychiatry, Harvard Medical School, Boston, MA, USA.

Abstract

Background: The aim of this study was to evaluate the construct validity of the psychosis module of the Mini International Neuropsychiatric Interview version 7.0.2 (MINI-7).

Method: We utilized data collected from 2738 participants with a primary psychotic or bipolar disorder. Participants were drawn from two Kenyan sites of a large multi-center neuropsychiatric genetic study. The factor structure of the MINI-7 psychosis items were explored using confirmatory factor analyses (CFA) and Item Response Theory approach, for the full sample and by gender.

Results: The CFA revealed that a 1-factor model provided adequate fit for the MINI-7 psychosis items for the full sample (x² = 397.92, df = 35, p < .0001; RMSEA = 0.06; CFI = 0.92; TLI = 0.90) as well as for the female (x² = 185.16.92, df = 35, p < .0001; RMSEA = 0.06; CFI = 0.93; TLI = 0.91) and male groups (x² = 242.09, df = 35, p < .0001; RMSEA = 0.06; CFI = 0.92; TLI = 0.89). Item thresholds for the full sample, and female and male groups were highest for 'odd beliefs' (-1.42, -1.33, and -1.51 respectively) and lowest for 'visual hallucinations' (-0.03, -0.04, and -0.01 respectively).

Limitations: Our study used a hospital-based population, which may have excluded patients with milder psychotic symptoms. Findings may therefore not be generalizable to the community setting.

Conclusions: Our findings indicate good construct validity of the MINI-7 psychosis module, and provides support for use of the tool in diagnosing psychotic disorders in clinical settings in Kenya.

Keywords: Factor structure; Item response; Kenya; Mini international neuropsychiatric interview; Psychometrics; Psychosis.

Publication types

Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't

MeSH terms

Adult
Factor Analysis, Statistical
Female
Humans
Kenya
Male
Psychiatric Status Rating Scales
Psychometrics
Psychotic Disorders* / diagnosis
Reproducibility of Results
Surveys and Questionnaires

Abstract

Publication types

MeSH terms

Grants and funding