Correlation between glucose measurement parameters of continuous flash monitoring and HbA1c. Real life experience in Asturias

Endocrinol Diabetes Nutr (Engl Ed). 2022 Aug-Sep;69(7):493-499. doi: 10.1016/j.endien.2022.08.001. Epub 2022 Aug 23.

Abstract

Introduction: Despite continuous glucose monitoring having been proven useful in patients with type 1 diabetes mellitus, A1C remains the gold standard for assessing disease management.

Material and methods: Descriptive, retrospective study which included 252 patients, 40.5% male, mean age 44.91±14.57 years, mean duration of diabetes 22.21±13.12 years, 88.1% on basal-bolus insulin therapy and 11.9% users of continuous subcutaneous insulin infusion. Glucose measurement, analytical and anthropometric data were obtained.

Results: The mean time in range was 60.18±15.60% and was associated with A1C after adjusting for age, gender, duration of diabetes, BMI, insulin regimen, %CV and time below range (ß: -0.548; p<0.01). The glucose management indicator (GMI) was 7.19±0.69% and was also associated with A1C (ß: 0.957; p<0.01) regardless of age, gender, duration of diabetes, BMI, insulin treatment, %CV and time in range. The average difference between A1C and GMI was 0.17±0.65% (-2.70-3.40%), being higher as A1C increased, in a linear and significant manner, without being influenced by the duration of diabetes or CV.

Conclusions: Although we found a positive correlation between continuous glucose monitoring glucose measurement parameters and A1C, there is still not enough evidence to replace one parameter with another.

Keywords: Continuous monitoring; Diabetes tipo 1; GMI; Monitorizacion continua; TIR; Type 1 diabetes.

MeSH terms

  • Adult
  • Blood Glucose
  • Blood Glucose Self-Monitoring*
  • Female
  • Glucose
  • Glycated Hemoglobin / analysis
  • Humans
  • Hypoglycemic Agents* / therapeutic use
  • Insulin / therapeutic use
  • Male
  • Middle Aged
  • Retrospective Studies

Substances

  • Blood Glucose
  • Glycated Hemoglobin A
  • Hypoglycemic Agents
  • Insulin
  • Glucose