Changes in Radical Levels as a Cause for the FLASH effect: Impact of beam structure parameters at ultra-high dose rates on oxygen depletion in water

Jeannette Jansen; Elke Beyreuther; Daniel García-Calderón; Leonhard Karsch; Jan Knoll; Jörg Pawelke; Michael Schürer; Joao Seco

doi:10.1016/j.radonc.2022.08.024

Changes in Radical Levels as a Cause for the FLASH effect: Impact of beam structure parameters at ultra-high dose rates on oxygen depletion in water

Radiother Oncol. 2022 Oct:175:193-196. doi: 10.1016/j.radonc.2022.08.024. Epub 2022 Aug 27.

Authors

Jeannette Jansen¹, Elke Beyreuther², Daniel García-Calderón³, Leonhard Karsch⁴, Jan Knoll³, Jörg Pawelke⁴, Michael Schürer⁵, Joao Seco⁶

Affiliations

¹ Division of Biomedical Physics in Radiation Oncology, German Cancer Research Center (DKFZ), Heidelberg, Germany.
² OncoRay - National Center for Radiation Research in Oncology, Faculty of Medicine and University Hospital Carl Gustav Carus, TU Dresden and Helmholtz-Zentrum Dresden-Rossendorf, Dresden, Germany; Helmholtz-Zentrum Dresden - Rossendorf (HZDR), Institute of Radiation Physics, Dresden, Germany.
³ Division of Biomedical Physics in Radiation Oncology, German Cancer Research Center (DKFZ), Heidelberg, Germany; Faculty of Physics and Astronomy, Ruprecht-Karls-University, Heidelberg, Germany.
⁴ OncoRay - National Center for Radiation Research in Oncology, Faculty of Medicine and University Hospital Carl Gustav Carus, TU Dresden and Helmholtz-Zentrum Dresden-Rossendorf, Dresden, Germany; Helmholtz-Zentrum Dresden - Rossendorf (HZDR), Institute of Radiooncology - OncoRay, Dresden, Germany.
⁵ National Center for Tumor Diseases Dresden (NCT/UCC), Germany: GermanCancer Research Center (DKFZ), Heidelberg, Germany; Faculty of Medicine and University Hospital Carl Gustav Carus, Technische Universität Dresden, Dresden,Germany; Helmholtz-Zentrum Dresden-Rossendorf (HZDR), Dresden, Germany.
⁶ Division of Biomedical Physics in Radiation Oncology, German Cancer Research Center (DKFZ), Heidelberg, Germany; Faculty of Physics and Astronomy, Ruprecht-Karls-University, Heidelberg, Germany. Electronic address: [email protected].

PMID: 36030933
DOI: 10.1016/j.radonc.2022.08.024

Abstract

The influence of different average and bunch dose rates in electron beams on the FLASH effect was investigated. The present study measures O₂ content in water at different beam pulse patterns and finds strong correlation with biological data, strengthening the hypothesis of radical-related mechanisms as a reason for the FLASH effect.

Keywords: FLASH effect; Oxygen depletion; Pulse structure; Radical reduction.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Humans
Oxygen*
Radiotherapy Dosage
Water*

Substances

Oxygen
Water