Structural Brain Correlates of Childhood Inhibited Temperament: An ENIGMA-Anxiety Mega-analysis

Janna Marie Bas-Hoogendam; Rachel Bernstein; Brenda E Benson; Kristin A Buss; Kelley E Gunther; Koraly Pérez-Edgar; Giovanni A Salum; Andrea P Jackowski; Rodrigo A Bressan; André Zugman; Kathryn A Degnan; Courtney A Filippi; Nathan A Fox; Heather A Henderson; Alva Tang; Selin Zeytinoglu; Anita Harrewijn; Manon H J Hillegers; Tonya White; Marinus H van IJzendoorn; Carl E Schwartz; Julia M Felicione; Kathryn A DeYoung; Alexander J Shackman; Jason F Smith; Rachael M Tillman; Yvonne H M van den Berg; Antonius H N Cillessen; Karin Roelofs; Anna Tyborowska; Shirley Y Hill; Marco Battaglia; Marco Tettamanti; Lea R Dougherty; Jingwen Jin; Daniel N Klein; Hoi-Chung Leung; Suzanne N Avery; Jennifer Urbano Blackford; Jacqueline A Clauss; Elizabeth P Hayden; Pan Liu; Matthew R J Vandermeer; H Hill Goldsmith; Elizabeth M Planalp; Thomas E Nichols; Paul M Thompson; P Michiel Westenberg; Nic J A van der Wee; Nynke A Groenewold; Dan J Stein; Anderson M Winkler; Daniel S Pine; ENIGMA-Anxiety Working Group

doi:10.1016/j.jaac.2022.04.023

Structural Brain Correlates of Childhood Inhibited Temperament: An ENIGMA-Anxiety Mega-analysis

J Am Acad Child Adolesc Psychiatry. 2022 Sep;61(9):1182-1188. doi: 10.1016/j.jaac.2022.04.023. Epub 2022 Jun 13.

Authors

Janna Marie Bas-Hoogendam¹, Rachel Bernstein², Brenda E Benson², Kristin A Buss³, Kelley E Gunther³, Koraly Pérez-Edgar³, Giovanni A Salum⁴, Andrea P Jackowski⁵, Rodrigo A Bressan⁵, André Zugman², Kathryn A Degnan⁶, Courtney A Filippi⁷, Nathan A Fox⁸, Heather A Henderson⁹, Alva Tang⁸, Selin Zeytinoglu⁸, Anita Harrewijn¹⁰, Manon H J Hillegers¹¹, Tonya White¹¹, Marinus H van IJzendoorn¹², Carl E Schwartz¹³, Julia M Felicione¹⁴, Kathryn A DeYoung⁸, Alexander J Shackman⁸, Jason F Smith⁸, Rachael M Tillman⁸, Yvonne H M van den Berg¹⁵, Antonius H N Cillessen¹⁵, Karin Roelofs¹⁵, Anna Tyborowska¹⁵, Shirley Y Hill¹⁶, Marco Battaglia¹⁷, Marco Tettamanti¹⁸, Lea R Dougherty⁸, Jingwen Jin¹⁹, Daniel N Klein²⁰, Hoi-Chung Leung²⁰, Suzanne N Avery²¹, Jennifer Urbano Blackford²², Jacqueline A Clauss¹³, Elizabeth P Hayden²³, Pan Liu²⁴, Matthew R J Vandermeer²³, H Hill Goldsmith²⁵, Elizabeth M Planalp²⁵, Thomas E Nichols²⁶, Paul M Thompson²⁷, P Michiel Westenberg²⁸, Nic J A van der Wee²⁹, Nynke A Groenewold³⁰, Dan J Stein³⁰, Anderson M Winkler², Daniel S Pine²; ENIGMA-Anxiety Working Group

Affiliations

¹ Leiden University, Leiden, the Netherlands; Leiden University Medical Center, Leiden, the Netherlands; Leiden Institute for Brain and Cognition, Leiden, the Netherlands; National Institute of Mental Health, Bethesda, Maryland. Electronic address: [email protected].
² National Institute of Mental Health, Bethesda, Maryland.
³ Pennsylvania State University, University Park.
⁴ Hospital de Clínicas de Porto Alegre, Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil.
⁵ Federal University of São Paulo, São Paulo, Brazil.
⁶ The Catholic University of America, Washington, DC.
⁷ National Institute of Mental Health, Bethesda, Maryland; University of Maryland, College Park.
⁸ University of Maryland, College Park.
⁹ University of Waterloo, Waterloo, Ontario, Canada.
¹⁰ Erasmus University Rotterdam, Rotterdam, the Netherlands.
¹¹ Erasmus University Medical Center, Rotterdam, the Netherlands.
¹² University College London, United Kingdom.
¹³ Massachusetts General Hospital, Harvard Medical School, Boston.
¹⁴ Tufts University, Medford, Massachusetts.
¹⁵ Radboud University Nijmegen, the Netherlands.
¹⁶ University of Pittsburgh School of Medicine, Pennsylvania.
¹⁷ University of Toronto, Ontario, Canada; Centre for Addiction and Mental Health, Toronto, Ontario, Canada.
¹⁸ University of Trento, Rovereto, Italy.
¹⁹ University of Hong Kong, Hong Kong.
²⁰ Stony Brook University, New York.
²¹ Vanderbilt University Medical Center, Nashville, Tennessee.
²² Vanderbilt University Medical Center, Nashville, Tennessee; University of Nebraska Medical Center, Omaha.
²³ Western University, London, Ontario, Canada.
²⁴ Western University, London, Ontario, Canada; North Dakota State University, Fargo.
²⁵ University of Wisconsin-Madison.
²⁶ University of Oxford, United Kingdom.
²⁷ University of Southern California, Marina del Rey.
²⁸ Leiden University, Leiden, the Netherlands; Leiden Institute for Brain and Cognition, Leiden, the Netherlands.
²⁹ Leiden University Medical Center, Leiden, the Netherlands; Leiden Institute for Brain and Cognition, Leiden, the Netherlands.
³⁰ University of Cape Town, Cape Town, South Africa.

Abstract

Temperament involves stable behavioral and emotional tendencies that differ between individuals, which can be first observed in infancy or early childhood and relate to behavior in many contexts and over many years.¹ One of the most rigorously characterized temperament classifications relates to the tendency of individuals to avoid the unfamiliar and to withdraw from unfamiliar people, objects, and unexpected events. This temperament is referred to as behavioral inhibition or inhibited temperament (IT).² IT is a moderately heritable trait¹ that can be measured in multiple species.³ In humans, levels of IT can be quantified from the first year of life through direct behavioral observations or reports by caregivers or teachers. Similar approaches as well as self-report questionnaires on current and/or retrospective levels of IT¹ can be used later in life.

Publication types

Research Support, Non-U.S. Gov't
Research Support, N.I.H., Intramural
Research Support, N.I.H., Extramural

MeSH terms

Anxiety Disorders
Anxiety* / psychology
Brain / physiology
Child, Preschool
Humans
Retrospective Studies
Temperament* / physiology

Abstract

Publication types

MeSH terms

Grants and funding