Ischemic Heart Disease in Young Women: JACC Review Topic of the Week

Margo B Minissian; Puja K Mehta; Sharonne N Hayes; Ki Park; Janet Wei; C Noel Bairey Merz; Leslie Cho; Annabelle Santos Volgman; Islam Y Elgendy; Mamas Mamas; Melinda B Davis; Harmony R Reynolds; Kelly Epps; Kathryn Lindley; Malissa Wood; Odayme Quesada; Gregory Piazza; Carl J Pepine

doi:10.1016/j.jacc.2022.01.057

Ischemic Heart Disease in Young Women: JACC Review Topic of the Week

J Am Coll Cardiol. 2022 Sep 6;80(10):1014-1022. doi: 10.1016/j.jacc.2022.01.057.

Authors

Margo B Minissian¹, Puja K Mehta², Sharonne N Hayes³, Ki Park⁴, Janet Wei⁵, C Noel Bairey Merz⁵, Leslie Cho⁶, Annabelle Santos Volgman⁷, Islam Y Elgendy⁸, Mamas Mamas⁹, Melinda B Davis¹⁰, Harmony R Reynolds¹¹, Kelly Epps¹², Kathryn Lindley¹³, Malissa Wood¹⁴, Odayme Quesada¹⁵, Gregory Piazza¹⁶, Carl J Pepine⁴

Affiliations

¹ Barbra Streisand Women's Heart Center, Smidt Heart Institute, Cedars-Sinai Medical Center, Los Angeles, California, USA; Brawerman Nursing Institute, Cedars-Sinai Medical Center, Los Angeles, California, USA. Electronic address: [email protected].
² Emory University School of Medicine, Atlanta, Georgia, USA.
³ Department of Cardiovascular Medicine, Mayo Clinic, Rochester, Minnesota, USA.
⁴ University of Florida, Gainesville, Florida, USA.
⁵ Barbra Streisand Women's Heart Center, Smidt Heart Institute, Cedars-Sinai Medical Center, Los Angeles, California, USA.
⁶ Cleveland Clinic, Lerner College of Medicine of Case Western Reserve University, Cleveland, Ohio, USA.
⁷ Rush College of Medicine, Rush Heart Center for Women, Chicago, Illinois, USA.
⁸ Division of Cardiovascular Medicine, Gill Heart Institute, University of Kentucky, Lexington, Kentucky, USA.
⁹ Keele Cardiovascular Research Group, Keele University, Keele, United Kingdom.
¹⁰ University of Michigan, Ann Arbor, Michigan, USA.
¹¹ Sarah Ross Soter Center for Women's Cardiovascular Research, NYU School of Medicine, New York, New York, USA.
¹² Inova Heart and Vascular Institute, Falls Church, Virginia, USA.
¹³ Vanderbilt University, Nashville, Tennessee, USA.
¹⁴ Massachusetts General Hospital, Boston, Massachusetts, USA.
¹⁵ Barbra Streisand Women's Heart Center, Smidt Heart Institute, Cedars-Sinai Medical Center, Los Angeles, California, USA; Women's Heart Center, The Christ Hospital Heart and Vascular Institute, Cincinnati, Ohio, USA.
¹⁶ Harvard Medical School, Division of Cardiovascular Medicine at the Brigham and Women's Hospital, Boston, Massachusetts, USA.

Abstract

The Cardiovascular Disease in Women Committee of the American College of Cardiology convened a working group to develop a consensus regarding the continuing rise of mortality rates in young women aged 35 to 54 years. Heart disease mortality rates in young women continue to increase. Young women have increased mortality secondary to ischemic heart disease (IHD) compared with comparably aged men and similar mortality to that observed among older women. The authors reviewed the published evidence, including observational and mechanistic/translational data, and identified knowledge gaps pertaining to young women. This paper provides clinicians with pragmatic, evidence-based management strategies for young women at risk for IHD. Next-step research opportunities are outlined. This report presents highlights of the working group review and a summary of suggested research directions to advance the IHD field in the next decade.

Keywords: disease; heart; ischemic; mortality; women.

Publication types

Review
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't

MeSH terms

Aged
Cardiovascular Diseases*
Female
Humans
Male
Myocardial Ischemia* / epidemiology
Risk Factors
Sex Factors

Abstract

Publication types

MeSH terms

Grants and funding