Objective: To explore the feasibility of applying quantitative analysis of the facial skin color to evaluate the severity of motion sickness objectively and to seek objective indicators that can reflect the severity of motion sickness. Methods: Motion sickness was induced in 51 male adult subjects recruited at the Air Force Medical University by Coriolis acceleration stimulation, and facial skin colorimetric values were acquired using a portable spectrophotometer at five time points: before stimulation and at 0 min, 10 min, 20 min and 30 min after the end of stimulation. The Graybiel rating scales were applied to assess the severity of motion sickness in subjects at each time point after stimulation, and the correlation between the magnitude of change in each colorimetric value and the maximum Graybiel's score was analyzed. The ROC curves were used to compare the evaluation performance of colorimetric value indicators which could reflect the severity of motion sickness. Results: Each colorimetric value in the CIE-L*a*b* color system changed significantly after exposure to provocative motion stimuli, and the trend was consistent with the typical sign of pallor in motion sickness. The magnitudes of the increase in the colorimetric value CIE-L*, the decrease in CIE-a*, and the increase in CIE-b* were all significantly and positively correlated with the maximum of Graybiel's scores (r=0.490 0, P=0.000 3; r=0.549 3, P<0.000 1; r=0.540 9, P<0.000 1). Comparing the performance of three colorimetric indicators to assess the severity of motion sickness, CIE-a* had an area under the ROC curve of 0.875 0, a sensitivity of 85.71%, and a specificity of 87.50%, which was better than CIE-L* and CIE-b*. Conclusions: The CIE-L*a*b* colorimeter values can be considered as objective indicators of the severity of motion sickness, among which the colorimetric indicator CIE-a* has the most diagnostic significance, and the method of quantitative analysis of the facial skin color can provide a new reference for the objective evaluation of the severity of motion sickness.
目的： 探索应用面部皮肤颜色定量分析客观评价运动病严重程度的可行性，寻求能够反映运动病严重程度的客观指标。 方法： 通过科里奥利加速度刺激诱发在空军军医大学招募的51名成年男性受试者［年龄（24.54±3.19）岁］出现运动病，使用便携式分光测色仪采集刺激前和刺激结束后第0、10、20、30 min 5个时间点的面部皮肤色度值，应用Graybiel运动病症状和体征评分量表评估受试者刺激后各时间点的运动病严重程度，分析各色度值变化幅度与Graybiel评分最大值之间的相关性，并利用受试者工作特征曲线（receiver operating characteristic curve，ROC）对可以反映运动病严重程度的色度值指标进行评估效能对比。使用SPSS 22.0等软件对数据进行统计学分析。 结果： CIE-L*a*b*表色系统中的各色度值在挑衅性运动刺激暴露后发生显著变化，变化趋势与运动病面色苍白的典型体征相符。色度值CIE-L*的增高幅度、CIE-a*的降低幅度、CIE-b*的增高幅度与Graybiel评分最大值均呈正相关（r=0.490 0，P=0.000 3；r=0.549 3，P<0.000 1；r=0.540 9，P<0.000 1）。对比3种色度值指标评估运动病严重程度的效能，CIE-a*的ROC曲线下面积0.875 0、敏感度85.71%、特异度87.50%，评估效能优于CIE-L*和CIE-b*。 结论： CIE-L*a*b*色度值可作为反映运动病严重程度的客观指标，尤以色度值指标CIE-a*最具诊断意义，面部肤色的定量分析方法可为客观评价运动病的严重程度提供参考。.