Executive summary: Japanese guidelines for atopic dermatitis (ADGL) 2021

Hidehisa Saeki; Yukihiro Ohya; Junichi Furuta; Hirokazu Arakawa; Susumu Ichiyama; Toshio Katsunuma; Norito Katoh; Akio Tanaka; Yuichiro Tsunemi; Takeshi Nakahara; Mizuho Nagao; Masami Narita; Michihiro Hide; Takao Fujisawa; Masaki Futamura; Koji Masuda; Tomoyo Matsubara; Hiroyuki Murota; Kiwako Yamamoto-Hanada; Committee for Clinical Practice Guidelines for the Management of Atopic Dermatitis 2021, The Japanese Society of Allergology, The Japanese Dermatology Association

doi:10.1016/j.alit.2022.06.009

Executive summary: Japanese guidelines for atopic dermatitis (ADGL) 2021

Allergol Int. 2022 Oct;71(4):448-458. doi: 10.1016/j.alit.2022.06.009. Epub 2022 Sep 2.

Authors

Hidehisa Saeki¹, Yukihiro Ohya², Junichi Furuta³, Hirokazu Arakawa⁴, Susumu Ichiyama⁵, Toshio Katsunuma⁶, Norito Katoh⁷, Akio Tanaka⁸, Yuichiro Tsunemi⁹, Takeshi Nakahara¹⁰, Mizuho Nagao¹¹, Masami Narita¹², Michihiro Hide¹³, Takao Fujisawa¹¹, Masaki Futamura¹⁴, Koji Masuda⁷, Tomoyo Matsubara¹⁵, Hiroyuki Murota¹⁶, Kiwako Yamamoto-Hanada²; Committee for Clinical Practice Guidelines for the Management of Atopic Dermatitis 2021, The Japanese Society of Allergology, The Japanese Dermatology Association

Affiliations

¹ Department of Dermatology, Nippon Medical School, Tokyo, Japan. Electronic address: [email protected].
² Allergy Center, National Center for Child Health and Development, Tokyo, Japan.
³ Medical Informatics and Management, Faculty of Medicine, University of Tsukuba, Tsukuba, Japan.
⁴ Kitakanto Allergy Research Institute, Kibounoie Hospital, Gunma, Japan.
⁵ Department of Dermatology, Nippon Medical School, Tokyo, Japan.
⁶ Department of Pediatrics, The Jikei University Daisan Hospital, Tokyo, Japan.
⁷ Department of Dermatology, Kyoto Prefectural University of Medicine Graduate School of Medical Science, Kyoto, Japan.
⁸ Department of Dermatology, Graduate School of Biomedical and Health Sciences, Hiroshima University, Hiroshima, Japan.
⁹ Department of Dermatology, Saitama Medical University, Saitama, Japan.
¹⁰ Department of Dermatology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan.
¹¹ Allergy Center, National Hospital Organization Mie National Hospital, Tsu, Japan.
¹² Department of Pediatrics, Faculty of Medicine, Kyorin University, Tokyo, Japan.
¹³ Department of Dermatology, Graduate School of Biomedical and Health Sciences, Hiroshima University, Hiroshima, Japan; Department of Dermatology, Hiroshima Citizens Hospital, Hiroshima, Japan.
¹⁴ Division of Pediatrics, National Hospital Organization Nagoya Medical Center, Nagoya, Japan.
¹⁵ Department of Pediatrics, Dokkyo Medical University Saitama Medical Center, Saitama, Japan.
¹⁶ Department of Dermatology, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan.

PMID: 36064654
DOI: 10.1016/j.alit.2022.06.009

Abstract

This is an abridged edition of English version of the Clinical Practice Guidelines for the Management of Atopic Dermatitis 2021. Atopic dermatitis (AD) is a disease characterized by relapsing eczema with pruritus as a primary lesion. In Japan, from the perspective of evidence-based medicine, the current strategies for the treatment of AD consist of three primary measures: (i) use of topical corticosteroids, tacrolimus ointment, and delgocitinib ointment as the main treatment of the inflammation; (ii) topical application of emollients to treat the cutaneous barrier dysfunction; and (iii) avoidance of apparent exacerbating factors, psychological counseling, and advice about daily life. In the present revised guidelines, the description about three new drugs, namely, dupilumab, delgocitinib, and baricitinib, has been added. The guidelines present recommendations to review clinical research articles, evaluate the balance between the advantages and disadvantages of medical activities, and optimize medical activity-related patient outcomes with respect to several important points requiring decision-making in clinical practice.

Keywords: Atopic dermatitis; Clinical practice guidelines; Clinical questions; Evidence-based medicine; Treatment.

Publication types

Review

MeSH terms

Dermatitis, Atopic* / drug therapy
Dermatitis, Atopic* / pathology
Emollients / therapeutic use
Glucocorticoids
Humans
Japan
Ointments / therapeutic use
Tacrolimus / therapeutic use

Substances

Emollients
Glucocorticoids
Ointments
Tacrolimus