Reduced PU.1 Expression Collaborates with Tet2 Loss to Trigger Myeloid Leukemogenesis

Blood Cancer Discov. 2022 Sep 6;3(5):378-381. doi: 10.1158/2643-3230.BCD-22-0100.

Abstract

The leukemic transformation of hematopoietic stem and progenitor cells in the setting of Tet2 deficiency is driven by PU.1 gene network loss through complementary reduction in PU.1 expression and hypermethylation of ETS loci at the enhancers of PU.1 target genes. See related article by Aivalioti et al., p. 444 (6).

Publication types

  • Editorial
  • Research Support, Non-U.S. Gov't
  • Research Support, N.I.H., Extramural
  • Comment

MeSH terms

  • Cell Transformation, Neoplastic / genetics
  • DNA-Binding Proteins / genetics
  • Dioxygenases* / genetics
  • Hematopoiesis
  • Humans
  • Leukemia, Myeloid*
  • Proto-Oncogene Proteins / genetics
  • Regulatory Sequences, Nucleic Acid
  • Trans-Activators / genetics

Substances

  • DNA-Binding Proteins
  • Proto-Oncogene Proteins
  • Trans-Activators
  • Dioxygenases
  • TET2 protein, human