Development of a Novel Molecular Test for Determining HPV Integration Status in HPV-Positive Oropharynx Cancers

Wesley H Stepp; T Danielle Samulski; Trevor G Hackman; Natalia Issaeva; Wendell G Yarbrough; Travis P Schrank

doi:10.1001/jamaoto.2022.2441

Development of a Novel Molecular Test for Determining HPV Integration Status in HPV-Positive Oropharynx Cancers

JAMA Otolaryngol Head Neck Surg. 2022 Oct 1;148(10):987-989. doi: 10.1001/jamaoto.2022.2441.

Authors

Wesley H Stepp^{1

2}, T Danielle Samulski^{1

3}, Trevor G Hackman¹, Natalia Issaeva^{1

2}, Wendell G Yarbrough^{1

2}, Travis P Schrank^{1

2}

Affiliations

¹ Lineberger Comprehensive Cancer Center, The University of North Carolina at Chapel Hill School of Medicine, Chapel Hill.
² Department of Otolaryngology-Head & Neck Surgery, The University of North Carolina at Chapel Hill School of Medicine, Chapel Hill.
³ Department of Pathology and Lab Medicine, The University of North Carolina at Chapel Hill School of Medicine, Chapel Hill.

No abstract available

Plain language summary

This diagnostic study describes the development of an assay for human papillomavirus–driven cancers of the oropharynx and the role viral integration could play in the process.

Publication types

Research Support, N.I.H., Extramural

MeSH terms

DNA, Viral
Humans
Oropharyngeal Neoplasms* / diagnosis
Oropharynx
Papillomaviridae / genetics
Papillomavirus Infections* / complications
Papillomavirus Infections* / diagnosis

Substances

DNA, Viral

Grants and funding

R01 DE027942/DE/NIDCR NIH HHS/United States