Practical application of mathematical calculations and statistical methods for the routine haematology laboratory

Background: Statistical analyses are embedded as critical functions in the routine haematology laboratory.

Aim: This educational article is aimed at providing an overview of these topics and practical application examples.

Materials, methods, and results: Topics covered include mathematical conversion between units, maintaining a quality control (QC) system, statistical methods for reagent validation, and determining uncertainty of measurement (UoM).

Discussion: Additional considerations may be required when a regional laboratory program is in place, such as the harmonization of INR results and determination of therapeutic reference intervals for unfractionated heparin therapy.

Conclusion: The coauthors of this manuscript are fortunate to be part of regional network of hospital laboratories, the Eastern Ontario Regional Laboratory Association (EORLA).