Condensation of DNA-Conjugated Imines with Homophthalic Anhydride for the Synthesis of Isoquinolones On-DNA

Josephine Yuen; Jing Chai; Yun Ding

doi:10.1007/978-1-0716-2545-3_12

Condensation of DNA-Conjugated Imines with Homophthalic Anhydride for the Synthesis of Isoquinolones On-DNA

Methods Mol Biol. 2022:2541:75-79. doi: 10.1007/978-1-0716-2545-3_12.

Authors

Josephine Yuen¹, Jing Chai², Yun Ding²

Affiliations

¹ Encoded Library Technologies/NCE Molecular Discovery, R&D Medicinal Science and Technology, GlaxoSmithKline, Cambridge, MA, USA. [email protected].
² Encoded Library Technologies/NCE Molecular Discovery, R&D Medicinal Science and Technology, GlaxoSmithKline, Cambridge, MA, USA.

PMID: 36083547
DOI: 10.1007/978-1-0716-2545-3_12

Abstract

Condensation of imines with anhydrides has been proven to be a valuable method for the synthesis of tetrahydroisoquinolines. Herein, we describe the application of this chemistry with DNA-conjugated imines. It is proven to be an efficient way to deliver isoquinolone chemotypes for DNA-encoded library.

Keywords: DNA-encoded library (DEL); Tetrahydroisoquinolines.

MeSH terms

Anhydrides*
DNA
Imines*
Molecular Structure

Substances

Anhydrides
Imines
DNA