Tetraphenylethylene sulfonate derivative as turn-on fluorescent sensor for berberine chloride detection in aqueous solution

Han-Jun Huang; Si-Yu Gao; Ai-Juan Zhao; Wittaya Ngeontae; Han-Chun Wu; Fu-Min Wang; Xiang-Kui Ren

doi:10.1016/j.jpba.2022.115030

Tetraphenylethylene sulfonate derivative as turn-on fluorescent sensor for berberine chloride detection in aqueous solution

J Pharm Biomed Anal. 2022 Oct 25:220:115030. doi: 10.1016/j.jpba.2022.115030. Epub 2022 Sep 6.

Authors

Han-Jun Huang¹, Si-Yu Gao¹, Ai-Juan Zhao¹, Wittaya Ngeontae², Han-Chun Wu³, Fu-Min Wang⁴, Xiang-Kui Ren⁵

Affiliations

¹ School of Chemical Engineering and Technology, State Key Laboratory of Chemical Engineering, Tianjin University, Tianjin 300350, PR China.
² Department of Chemistry, Faculty of Science, Khon Kaen University, Khon Kaen 40002, Thailand.
³ School of Physics, Beijing Institute of Technology, Beijing 100081, PR China.
⁴ School of Chemical Engineering and Technology, State Key Laboratory of Chemical Engineering, Tianjin University, Tianjin 300350, PR China. Electronic address: [email protected].
⁵ School of Chemical Engineering and Technology, State Key Laboratory of Chemical Engineering, Tianjin University, Tianjin 300350, PR China; Guangdong Provincial Key Laboratory of Luminescence from Molecular Aggregates, South China University of Technology, Guangzhou 510640, PR China. Electronic address: [email protected].

PMID: 36088810
DOI: 10.1016/j.jpba.2022.115030

Abstract

A negatively-charged tetraphenylethylene derivative (TPE-SE) was designed and synthesized as turn-on fluorescent sensor for berberine chloride (BBC) detection in aqueous solution. The fluorescent property and detection mechanism were elucidated by UV-vis absorption spectra, photoluminescence spectra, dynamic light scattering experiments. The results reveal that the BBC can lead to aggregation-induced emission of TPE-SE due to the electrostatic interactions, endowing TPE-SE with excellent turn-on detecting ability, high selectivity and sensitivity to BBC. The detection limit is as low as 6.58 × 10^-6M. These results should be applicable to fabricate special turn-on fluorescent sensors towards various antibiotics, and it is crucially important for achieving reasonable control and intake of small biomolecules.

Keywords: Aggregation-induced emission; Berberine chloride; Fluorescence sensor; Tetraphenylethylene; Turn-on.

MeSH terms

Alkanesulfonates
Anti-Bacterial Agents
Berberine*
Chlorides
Fluorescent Dyes
Spectrometry, Fluorescence / methods
Stilbenes
Water

Substances

Alkanesulfonates
Anti-Bacterial Agents
Chlorides
Fluorescent Dyes
Stilbenes
tetraphenylethylene
Water
Berberine