Clinicopathologic Features and Treatment of CD10-Positive Mantle Cell Lymphoma: A Case Report and Review of Literature

Christopher Hino; Bryan Pham; Austin L Gray; Jun Wang; Dan Ran Castillo; Mojtaba Akhtari; Yan Liu

doi:10.3389/pore.2022.1610588

Clinicopathologic Features and Treatment of CD10-Positive Mantle Cell Lymphoma: A Case Report and Review of Literature

Pathol Oncol Res. 2022 Aug 25:28:1610588. doi: 10.3389/pore.2022.1610588. eCollection 2022.

Authors

Christopher Hino¹, Bryan Pham¹, Austin L Gray², Jun Wang², Dan Ran Castillo³, Mojtaba Akhtari³, Yan Liu²

Affiliations

¹ Department of Internal Medicine, Loma Linda University Medical Center, Loma Linda, CA, United States.
² Department of Pathology, Loma Linda University, Loma Linda, CA, United States.
³ Department of Oncology/Hematology, Loma Linda University, Loma Linda, CA, United States.

Abstract

Mantle cell lymphoma (MCL) is a rare and aggressive non-Hodgkin's B cell lymphoma characterized by the translocation t(11;14) (q13;32) and overexpression of CCND1. MCL is immunophenotypically identified as CD20⁺, CD5⁺, CyclinD1+, CD43⁺, CD10^-, BCL6^-, and CD23^-. It is often distinguished from B cell lymphomas of germinal center cell origin by the absence of CD10 expression. Here we report the unique clinicopathologic features of a patient with CD10⁺ MCL with gastrointestinal involvement and review current literature identifying this unique immunophenotype.

Keywords: B-cell chronic lymphoproliferative disorders; CCND1; CD10; case report; immunophenotyping; mantle cell lymphoma.

Publication types

Case Reports
Review

MeSH terms

Adult
Humans
Immunophenotyping
In Situ Hybridization, Fluorescence
Lymphoma, B-Cell* / pathology
Lymphoma, Mantle-Cell* / drug therapy
Lymphoma, Mantle-Cell* / genetics
Lymphoma, Mantle-Cell* / metabolism
Neprilysin
Translocation, Genetic

Substances

Neprilysin