Intact amphetamine-induced behavioral sensitization in mice with increased or decreased neuronal glutamate transporter SLC1A1/EAAT3

Muhammad O Chohan; Hannah Yueh; Halli Fein; Jared M Kopelman; Susanne E Ahmari; Jeremy Veenstra-VanderWeele

doi:10.1016/j.neuint.2022.105418

Intact amphetamine-induced behavioral sensitization in mice with increased or decreased neuronal glutamate transporter SLC1A1/EAAT3

Neurochem Int. 2022 Nov:160:105418. doi: 10.1016/j.neuint.2022.105418. Epub 2022 Sep 9.

Authors

Muhammad O Chohan¹, Hannah Yueh¹, Halli Fein², Jared M Kopelman³, Susanne E Ahmari⁴, Jeremy Veenstra-VanderWeele⁵

Affiliations

¹ Department of Psychiatry, Columbia University, New York, NY, USA; New York State Psychiatric Institute, New York, NY, USA.
² New York State Psychiatric Institute, New York, NY, USA; Department of Neuroscience and Behavior, Barnard College of Columbia University, New York, NY, USA.
³ Department of Psychiatry, Translational Neuroscience Program, University of Pittsburgh, Pittsburgh, PA, USA; Center for the Neural Basis of Cognition, Carnegie Mellon University, Pittsburgh, PA, USA.
⁴ Department of Psychiatry, Translational Neuroscience Program, University of Pittsburgh, Pittsburgh, PA, USA; Center for the Neural Basis of Cognition, Carnegie Mellon University, Pittsburgh, PA, USA. Electronic address: [email protected].
⁵ Department of Psychiatry, Columbia University, New York, NY, USA; New York State Psychiatric Institute, New York, NY, USA. Electronic address: [email protected].

PMID: 36096294
DOI: 10.1016/j.neuint.2022.105418

Abstract

Repeated amphetamine treatment results in locomotor sensitization, a phenomenon that may relate to the development of psychosis and addiction. Evidence suggests that interactions between dopaminergic and glutamatergic systems are involved in amphetamine sensitization. We previously demonstrated that the neuronal excitatory amino acid transporter (Slc1a1/EAAT3) produces bidirectional, expression-dependent effects on the response to acute amphetamine. Here, using mice with decreased or increased expression of EAAT3, we found that chronic alterations in EAAT3 expression do not significantly impact amphetamine-induced locomotor sensitization. Compensation by other glutamate transporters cannot be ruled out in this important neuroadaptive phenomenon.

Keywords: Amphetamine; Basal ganglia; Dopamine; EAAT3; Glutamate transporters; Sensitization.

Published by Elsevier Ltd.

Publication types

Research Support, N.I.H., Extramural

MeSH terms

Amphetamine* / pharmacology
Animals
Dopamine
Excitatory Amino Acid Transporter 3* / genetics
Excitatory Amino Acid Transporter 3* / metabolism
Glutamic Acid / metabolism
Mice
Neurons / metabolism

Substances

Excitatory Amino Acid Transporter 3
Slc1a1 protein, mouse
Glutamic Acid
Amphetamine
Dopamine