The Impact of SARS-CoV-2 Variants on the Clinical Phenotype and Severity of Multisystem Inflammatory Syndrome in Children in South Africa

Pediatr Infect Dis J. 2022 Dec 1;41(12):e510-e512. doi: 10.1097/INF.0000000000003691. Epub 2022 Sep 5.

Abstract

The effects of SARS-CoV-2 variants on disease phenotype and severity of multisystem inflammatory syndrome in children (MIS-C) are unknown. We compared the clinical phenotype of MIS-C in 129 South African children across four distinct (Ancestral type, Beta, Delta, and Omicron) variant-driven waves and found that MIS-C remains a severe disease with a stable clinical presentation, regardless of variant.

Publication types

  • Research Support, N.I.H., Extramural

MeSH terms

  • COVID-19*
  • Humans
  • Phenotype
  • SARS-CoV-2* / genetics
  • South Africa / epidemiology
  • Systemic Inflammatory Response Syndrome / diagnosis

Supplementary concepts

  • SARS-CoV-2 variants
  • pediatric multisystem inflammatory disease, COVID-19 related