A counterintuitive antibody cocktail disrupts coxsackievirus

Seth J Zost; Matthew R Vogt

doi:10.1016/j.chom.2022.08.010

A counterintuitive antibody cocktail disrupts coxsackievirus

Cell Host Microbe. 2022 Sep 14;30(9):1194-1195. doi: 10.1016/j.chom.2022.08.010.

Authors

Seth J Zost¹, Matthew R Vogt²

Affiliations

¹ Vanderbilt Vaccine Center, Vanderbilt University Medical Center, Nashville, TN, USA.
² Department of Pediatrics, Division of Infectious Diseases, and Department of Microbiology & Immunology, University of North Carolina at Chapel Hill School of Medicine, Chapel Hill, NC, USA. Electronic address: [email protected].

Abstract

Utilizing monoclonal antibodies to prevent and treat infectious diseases has been accelerated by the COVID-19 pandemic. In this issue of Cell Host & Microbe, Zheng et al. show how a three-monoclonal-antibody cocktail, that defies conventions of "rational design" for a therapeutic agent, functions cooperatively to disrupt coxsackievirus virions.

Publication types

Comment

MeSH terms

Antibodies, Monoclonal / therapeutic use
COVID-19*
Enterovirus*
Humans
Pandemics
Virion

Substances

Antibodies, Monoclonal

Grants and funding

K08 AI156125/AI/NIAID NIH HHS/United States