Dips in dopamine say "no" to nicotine

Alice Servonnet; Saleem M Nicola

doi:10.1016/j.neuron.2022.08.021

Dips in dopamine say "no" to nicotine

Neuron. 2022 Sep 21;110(18):2895-2898. doi: 10.1016/j.neuron.2022.08.021.

Authors

Alice Servonnet¹, Saleem M Nicola²

Affiliations

¹ Dominick P. Purpura Department of Neuroscience, Albert Einstein College of Medicine, Bronx, NY 10461, USA.
² Dominick P. Purpura Department of Neuroscience, Albert Einstein College of Medicine, Bronx, NY 10461, USA; Department of Psychiatry, Albert Einstein College of Medicine, Bronx, NY 10461, USA. Electronic address: [email protected].

PMID: 36137519
DOI: 10.1016/j.neuron.2022.08.021

Abstract

Nicotine has both rewarding and aversive effects. In this issue of Neuron, Liu et al. show that nicotine aversion depends on both desensitization of high-affinity nicotinic acetylcholine receptors (nAChRs) that activate midbrain dopamine neurons and activation of low-affinity nAChRs that inhibit dopamine neurons via the laterodorsal tegmental nucleus (LDT).

Publication types

Comment

MeSH terms

Animals
Dopamine
Dopaminergic Neurons / metabolism
Mice
Mice, Inbred C57BL
Nicotine* / pharmacology
Nicotinic Agonists / pharmacology
Receptors, Nicotinic* / metabolism
Ventral Tegmental Area / physiology

Substances

Nicotinic Agonists
Receptors, Nicotinic
Nicotine
Dopamine