The brain-immune ecosystem: Implications for immunotherapy in defeating neurodegenerative diseases

Michal Schwartz; Miguel A Abellanas; Afroditi Tsitsou-Kampeli; Stefano Suzzi

doi:10.1016/j.neuron.2022.09.007

The brain-immune ecosystem: Implications for immunotherapy in defeating neurodegenerative diseases

Neuron. 2022 Nov 2;110(21):3421-3424. doi: 10.1016/j.neuron.2022.09.007. Epub 2022 Sep 22.

Authors

Michal Schwartz¹, Miguel A Abellanas², Afroditi Tsitsou-Kampeli², Stefano Suzzi²

Affiliations

¹ Department of Brain Sciences, Weizmann Institute of Science, Rehovot, Israel. Electronic address: [email protected].
² Department of Brain Sciences, Weizmann Institute of Science, Rehovot, Israel.

PMID: 36150394
DOI: 10.1016/j.neuron.2022.09.007

Abstract

Recent functional and anatomical discoveries of brain-immune relationships have overturned previous beliefs regarding the brain's immune privilege. Here, we propose that the brain and immune cells at its borders operate as an "ecosystem" to support the brain's robustness and resilience. Modulation of this ecosystem can be harnessed in the clinic.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Brain
Humans
Immunotherapy
Neurodegenerative Diseases* / therapy